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endopeel chemistry

Basics Chemistry about Endopeel

The main ingredients to realize endopeel technics are :

  • phenic acid 
  • peanuts oil acid

Phenic Acid

Phenic Acid ,Carbolic Acid and Phenol have been considered similar for most organic chemistry engineers as medical doctors, pharmacists ...

In fact Endopeels carbolic acid as endopeels phenic acid are weak acids with pKa <7 and phenol has a pKa>7 .

That means that carbolic acid and phenol like on the image are same in organic chemistry formula development, but they are completely different concerning endopeel in general chemistry and physico chemistry.

There are 3 main differences :

  1. Resonance stabilization of the phenoxide anion by the aromatic ring.In this way, the negative charge on oxygen is shared by the ortho and para carbon atoms. That is why endopeels carbolic acid is used instead of phenol for endopeel techniques ( which lead to medical liftings obtained by chemical myoplasty, myopexy and myotension)
  2. Increased acidity in the result of orbital overlap between the oxygen's lone pairs and the aromatic system.
  3. The dominant effect is the induction from the sp2 hybridized carbons;the comparatively more powerful inductive withdrawal of electron density 

Resonance Structures for Phenol


1-Dewandre L., Tenenbaum A.. Chemical Peels of Drs. Mark G. Rubin and Rebecca Tung 2 nd Edition. Imprint: Saunders. Chapter 1: Chemistry of Peelings and Hypothesis of the Mechanism of Action ISBN: 978-1-4377-1924-6. Copyright: 2011

Equation of Henderson Hasselbach

Legend :

  • HA represents the molecular form of the weak acid with where H is the atom of hydrogen
  • A- represents the anion and H+ the proton, which in solution leads to the ion hydronium H30+
  • Ka is the constant of acidity .

   The pKa of endopeel phenic acid is 6.65 vs the pKa of phenol is 9.95.

Definitions of important terms in stereochemistry.

  • Stereoisomers

    Have similar molecular formula but differ in spatial orientation of their atoms.

  • Enantiomers

    are 2 stereoisomers with non-superimposable mirror images.

  • Distomer

    Enantiomer with lower biological activity.

  • Eutomer

    Eniantomer with higher biological activity

  • Racemate

    A mixture of equal amounts of enantiomers.

  • Chiral Switch

    A rasemate switch to single enantiomer.

  • Epimerization

    Bioinversion of enantiomers.

  • (+) Optical Isomer

    Rotate the light plane clockwise (dextrorotary).

  • (-) Optical Isomer

    Rotate the light plane counter-clockwise (levorotary).

  • (R) and (L)

    According to enantiomer configurations which are right or -left handed.

The chirality of Phenols

Phenols exhibit chirality within their molecules.

This chirality is due to the absence of planar and axial symmetry in the phenol molecule.

Scientific Definition

A molecule that is not superimposable is said to be chiral.
mirror hands

Ex :Left and right hands are mirror images but arent superimposable.

Chirality For Dummies

Chemically Similar but Structurally Different
chirality for dummies

Hitler was a criminal nazi and Chaplin was a comic Jew


Interactions Implications for the Tissues

Molecule fits Receptor Site

Leading to a Response

Molecule doesnt fit Receptor Site

No Response


Enantiomers of phenol will interact with the skin and muscles differently
  • The enantiomers of phenol are similar by their formula but their shape is different .
  • Like a key in a lock,only the chirally correct form ( here the endopeels phenic acid) can interact with the appropriate cell receptor and trigger the right cellular response.
  • The ,,wrong,, form of the phenol can collect on the skin s surface and can cause necrosis and big edema.

Ignorance & Prejudges

Einstein used to say that it was easier to break an atome than to break prejudges.

We do not have the right to open our mouth if our mind is close.

Courteline :

in french :
Passer pour un idiot aux yeux d un imbécile est un plaisir de fin gourmet.

Translated into english:
Look like an idiot in the eyes of a fool is a fun foodie

Albert Einstein
Georges Courteline